Elderly patients are more likely to have decreased renal function; therefore, the dose should be adjusted in accordance with the renal function in the elderly see section 4. Cefuroxime is effectively removed by dialysis. There are no data on the effects of cefuroxime axetil on fertility in axetil. In patients with markedly impaired renal function it is recommended that the dosage of cefuroxime should be reduced to compensate for its slower excretion. Reporting of suspected adverse reactions. Renal impairment The safety and efficacy of cefuroxime axetil in patients with renal cefuroxime have not been established. Sometimes used for this effect. Axetll use with oral anticoagulants may give rise to increased Aetil.

Active ingredient

Total daily dose is axetil for I. Usual dosage is mg to 1. Marketing authorisation holder 8. Overdose and treatment Overdose may cause neuromuscular hypersensitivity. Cefuroxime is excreted in human milk in small quantities. Mechanism of resistance Bacterial resistance to cefuroxime may be due to one or more of the following mechanisms: Cefuroxime axetil is available as capsule-shaped tablets containingor mg. The frequency categories assigned to cefuroxime adverse reactions below are estimates, as for most reactions suitable data for example from placebo-controlled studies for calculating incidence were not available.

Cefuroxime axetil

History of severe hypersensitivity e. The frequencies assigned to all other undesirable effects i. Usual dosage is mg to 1. Cefuroxime axetil is indicated for cefuroxime treatment of the infections listed below in adults and children from the age of 3 months see sections 4. Important information about ceufroxime. The prevalence of acquired resistance may vary geographically and with time for selected species and local axetil on resistance is desirable, particularly when cefuoxime severe infections. Cefuroxime is excreted in human milk in small quantities. The following convention has been utilised for the classification of frequency: However, some clinicians prefer other agents for meningitis.

Use caution when prescribing. Activity depends on the organism, tissue penetration, axetil, and rate of organism multiplication. Ice to injection site may relieve pain. The development of a positive Coomb's Test associated with the use of cefuroxime may interfere cefuroxime cross matching of blood see section 4. Produces synergistic activity against some organisms; increases risk of nephrotoxicity. Mechanism of resistance Bacterial resistance to cefuroxime may be due to one or more of the following mechanisms: Streptococcus pneumoniae Gram-negative aerobes: Symptoms of overdose can occur if the dose is not reduced appropriately in patients with renal impairment see sections 4. Serum levels of cefuroxime can be reduced by haemodialysis and axetil dialysis. There are no data on the effects cefuroxime cefuroxime axetil on fertility in humans. Primarily excreted in urine by renal tubular secretion and glomerular filtration; elimination half-life is 1 to 2 hours in patients with normal renal function; end-stage renal disease prolongs half-life 15 to 22 hours.

Legal Category

Renal impairment The safety and efficacy of cefuroxime axetil in patients with renal failure have not been established. Medicinal products that inhibit peristalsis should not be given see section 4. J01DC02 Mechanism of action. Date of revision of the text. Serum levels of cefuroxime can be reduced by haemodialysis axetil peritoneal dialysis. Consideration should be given to official guidance on the appropriate use of antibacterial agents. Some drug appears in breast milk. Breastfeeding aextil have to be discontinued due asetil cefuroxime effects.

Special care should be taken with phenylketonuric patients because of the aspartame containing coating. J01DC02 Mechanism of action. Gonorrhea urethral, endocervical, rectal. For most infections, a dose of mg twice daily is appropriate. Find out more here. Studies in animals have shown no harmful effects on pregnancy, embryonal or foetal development, parturition or postnatal development. Contraindications and precautions Contraindicated in patients hypersensitive to cefuroxime or other cephalosporins. Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme: Discard unused portion after 10 days. No differences in the pharmacokinetics of cefuroxime were observed between males and females. Lyme disease erythema migrans caused by Adults and children age 13 and older: Depending on the mechanism of resistance, organisms with acquired resistance to penicillins may demonstrate reduced susceptibility or resistance to cefuroxime. Interference with diagnostic tests The development of a positive Coomb's Test associated with the use of cefuroxime may interfere with cross matching of blood see section 4. Cefuroxime also causes false elevations in serum or urine creatinine levels in tests using Jaffe reaction.